1. vitamin d activation Review – Adult Dog Multivitamin by Primo Pup Vet Health | Supports Physical & Mental Wellbeing | Vet Formulated | Easy to Digest | No Artificial Colors, Flavors, or Grains | Made in the USA | 60 Chewables

vitamin d activation REVIEW – IMAGE SOURCE AMAZON

• VETERINARIAN FORMULATED SPECIFICALLY FOR THE ADULT STAGE. Nose to tail support made in the USA with the highest quality ingredients. Certified by the National Animal Supplement Council.
• VITAL ORGAN SUPPORT: Promotes the health of major organs throughout the body, including the formation of bones, cartilage, teeth, red blood cells and soft tissue. Supports the liver, muscular function and vision. Helps to maintain the tissue of the lungs, intestines and skin. Supports coat health.
• METABOLISM AID, ENSURES COMPETE NUTRITION: Supports growth and encourages a healthy appetite. Aids in carbohydrate, fat and protein metabolism as well as vitamin and mineral absorption and metabolism. Supports energy production and enzyme activation. Helps to maintain proper hydration and electrolyte balance.
• MENTAL HEALTH & IMMUNE SYSTEM SUPPORT: Aids in nerve transmission provides support in times of stress. Antioxidant formula promotes immune system health.
• MONEY BACK GUARANTEE: We are confident your dog will love and benefit from our super tasty Adult Dog Multivitamin. Buy risk free with our 100% satisfaction, 30 day money-back guarantee.

Veterinarian Formulated Multivitamin for Adult Dogs

Primo Pup® Adult Multivitamins supplement essential vitamins and nutrients lost in dog food manufacturing and those absent from raw food diets. The benefits of supplementing a pet’s diet have been well documented, and account for deficiencies in key vitamins and nutrients in the diet. Our premier multivitamin and multimineral formula ensures your dog’s diet contains adequate nutrition and promotes physical and mental wellbeing for a healthy and happy prime stage of life!

Effective Formula, Quality Ingredients and Taste Your Dog Will Love

•Formulated specifically for the adult life stage to support overall physical and mental wellbeing.

•Complete multivitamin/mineral formula ensures dog’s diet contains adequate nutrition in an easy to digest formula.

•Supplements vitamins and nutrients lost in dog food manufacturing and those absent from raw food diets.

Veterinarian Developed Therapeutic Support – Made in the USA – Quality and Purity Assured

•Veterinarian formulated.

•Made with quality ingredients in a facility meeting human consumption standards.

•Made in the USA.

•Made with Certified Good Manufacturing Practices.

•Lab tested for quality and purity.

•Certified by the National Animal Supplement Council.

•100% grain free.

•No artificial colors or flavors.

At Primo Pup, We Obsess About Helping Pets Live Healthier Lives

Training Tip: We recommend administering the appropriate dose as a reward for completing a task/command/trick to provide a daily training routine that both you and your dog will look forward to.

Contains 60 super tasty liver flavor chewables.

2. vitamin d activation Review – Plasminogen: Structure, Activation, and Regulation: Structure, Activation and Regulation

vitamin d activation REVIEW – IMAGE SOURCE AMAZON

inthisresearchfieldandthemanyexcitingdiscoveriessuggeststhattheresearchefforts inthenextdecadewillrevealthemechanismsbywhichthecomponentsoftheplas­ minogensysteminteractandregulatebothplasminactivationandfunctionatacellular level. Plasminogen: Structure, activation, and regulationisdividedintotwosections. Thefirstsectiondealswiththestructureandregulationofplasminogen. Thechapters inthissectionrangefromdiscussionsofthestructureofplasminogenandtheregulation oftheplasminogengenetodiscussionsofthestructureandregulationofplasminogen activatorsandplasminogenactivatorinhibitors. Alsoexaminedistherelativelynewdata concerningthegenerationofanti-angiogenicmoleculesfromplasminogen. Thesecond sectiondealswiththephysiologicalandpathophysiologicalrolesofplasminogenaswell astheconsequencesofplasminogengeneknockout. Discussionsinthissectioninclude examinationoftheroleofplasminogeninhematopoieticmalignancies,tumorcell progression,angiogenesis,mammaryglandinvolution,woundhealing,andbone readsorption. xi xii Preface Inclosing,Iwouldliketothankmyadministrativeassistant,Ms. ViSommerfeld,for herinvaluableassistanceandtimelesseffortswiththeorganizationandeditingofthebook. Lastly,Iwouldliketoacknowledgetheeffortsoftheauthorsoftheindividualchapters, whoareauthorities inthisfield,foragreeingtotaketimefrombusyschedulestoprovide thesechaptersinatimelyfashion. DavidMortonWaisman Contents Part I. Plasminogen: Structure and Regulation 1. Human Plasminogen: Structure, Activation, and Function FrancisJ. Castellino and Victoria A. Ploplis 1. Introduction 3 2. StructureofHumanPlasminogen. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 2. 1. PrimaryProteinStructure. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 2. 2. GeneOrganization 5 3. ActivationofHumanPlasminogen. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 3. 1. ActivationbyPhysiologicalActivators 7 3. 1. 1. Urokinase-typePlasminogenActivator. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 3. 1. 2. Tissue-typePlasminogenActivator. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 3. 2. ActivationbyBacterial-derivedPlasminogenActivators. . . . . . . . . . . . . . . . . . . . . 9 3. 2. 1. Streptokinase 9 3. 2. 2. Staphylokinase. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 4. TargetsforPlasminActivity. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 5. DysplasminogenemiasandPhenotypicManifestations 10 6. Conclusions 11 References. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11 2. Plasminogen Activators: Structure and Function Vincent Ellis 1. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19 2. SerineProteases. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 20 3. UrokinasePlasminogenActivator,uPA. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 21 3. 1. SerineProteaseDomain 22 3. 2. N-terminalDomains. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 24 3. 2. 1. KRModule 24 3. 2. 2. EGModule 24 4. MechanismsRegulatinguPAFunction. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25 4. 1. ZymogenActivation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25 4. 2. ZymogenActivity. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26 4. 3. ReciprocalZymogenActivation 27 4. 4. uPARStimulationofPlasminogenActivation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 27 4. 4. 1. uPAandtheTemplateMechanism 28 4. 4. 2. PlasminogenandtheTemplateMechanism 29 4. 5. AvianuPA,aSpecialCase? 30 xiii xi

3. vitamin d activation Review – 8X Strength Natural Vitamin K2 Formula. Provides 4-in-1 Support with MK-7, MK-4, K1 and D3 with Maximum Absorption for Stronger Bones and Cardiovascular Health 60 Capsules

vitamin d activation REVIEW – IMAGE SOURCE AMAZON

• ♥ A FULL SPECTRUM FORMULA: Provides 2 types of Vitamin K2: MK4 (Menatetrenone -4), MK7 (Menaquinone-7), Plus Vitamin K1 and Vitamin D3 for optimal results
• ♥ STRONGER BONES: Helps transport and direct Calcium from the bloodstream and store it in the bones and teeth.
• ♥ SUPPORT CARDIOVASCULAR HEALTH: Vitamin K2 keeps calcium out of your arterial lining, preventing calcification of coronary arteries.
• ♥ MAXIMUM ABSORPTION: With superior bioavailability of Menaquionone-7, combined with Vitamin D3, Vitamin K2 is absorbed and utilized most efficiently
• ♥ HIGHEST QUALITY: To ensure purity and safety, our products are manufactured in a fully GMP-certified facility. All Made in USA.

COMBINATION OF 4 ESSENTIAL VITAMINS: K1, K2-MK4, K2-MK7 & D3 FOR MAXIMUM BENEFITS

Not all forms of vitamin K are created equal. Each has its own unique benefit. We have specially designed this K2 formula to ensure you get the maximum and broadest range of benefits that vitamin K can offer. We included Vitamin D3 to ensure proper vitamin K absorption. Sufficient Vitamin D3 facilitates calcium absorption, while Vitamin K transports it to each of the bodily systems that necessitate this essential nutrient.

HIGH ABSORPTION FOR MAXIMUM BIOAVAILABILITY

Research has shown that a single dose of MK-7 was well absorbed and reached its fully absorbed level at 6 hours after intake and can continue to provide support in the body for up to 2 days after consumption. Results can be detected and measured through blood tests at the nutritional level. Outcomes of testing prove that long chain MK-7 is highly absorbable. The advanced effectiveness of MK-7 is due to its improved bioavailability, making it the longest lasting form of vitamin K available.

SUPPORTS BONE HEALTH

Bone tissues which include the hard outer shell and inner spongy tissue, are replaced, roughly every 7 years. Vitamin K2 has a significant role in facilitating the activation and optimizing of a protein called Osteocalcin along with all its functions. This protein helps bind calcium into the bone matrix during the osteoblasts process.

SUPPORTS CARDIOVASCULAR HEALTH

Vitamin K2 not only helps direct calcium to bind and deposit in the bone but also helps direct the calcium away from where it should not belong, such as organs, arteries, and joint spaces. Vitamin K2 helps this process by activating the production thereby increasing the level of matrix GLA protein (MGP) produced by the smooth vascular muscles cells. This protein helps inhibit the accumulation of calcium in the walls of blood vessels. Without Vitamin K2, unwanted calcification in the arterial lining may occur.